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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16577 | PRMT5-IN-2 | Histone Methyltransferase | |
PRMT5-IN-2 is an inhibitor of protein arginine methyltransferase 5. | |||
T79274 | PRMT5-IN-31 | Histone Methyltransferase | |
PRMT5-IN-31 (Compound 3m), a selective PRMT5 inhibitor (IC50: 0.31 μM), increases hnRNP E1 protein levels by occupying the substrate site of PRMT5 and establishing key interactions with amino acid residues. It exhibits a... | |||
T36630 | MRTX9768 hydrochloride | ||
MRTX9768 hydrochloride is a potent, orally active PRMT5 inhibitor. MRTX9768 hydrochloride is a synthetic lethal-based inhibitor binding the PRMT5-MTA complex[1]. MRTX9768 inhibits SDMA and cell proliferation in HCT116 MT... | |||
T79275 | Antiproliferative agent-25 | Histone Methyltransferase | |
Antiproliferative Agent-25 (Compound 3s4) is a selective PRMT5 inhibitor displaying an IC50 of 0.11 μM. It elevates hnRNP E1 protein levels and forms hydrogen bond interactions with SAM and the E444 residue of PRMT5. Thi... |